INSPIRE Therapy
Pulsed electric field treatments for inoperable tumors
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INSPIRE Therapy

Inspiring Hope for Incurable Cancers

Overview

 

INSPIRE Therapy uses ultrashort electrical pulses to target and destroy cancer cells by disrupting the cell and organelle membranes.

 

This technique enables clinicians to treat inoperable tumors which form in challenging locations near major blood vessels, nerves, or other critical structures.

 

Our laboratory develops the instrumentation, software, and treatment planning algorithms necessary to implement this technique in a clinical setting.

Clinical Translation

 

Our laboratory is currently investigating the use of INSPIRE therapy against multiple forms of inoperable tumors which form in the brain, liver , and pancreas.

 

In addition, we are developing combinatorial techniques to address breast, skin, lung and kidney cancers with the goal of reducing systemic toxicity associated with standard of care treatments and inducing a systemic vaccine like immune response against metastatic disease.

 

We use a combination of in vitro 3D tumor models and benchtop perfused organ models to evaluate clinically relevant protocols, applicators, and instrumentation.

 

These techniques are then evaluated with intent to treat in veterinary patients with spontaneous cancers to validate new protocols in preparation for translation to human clinical patients.

Ongoing Clinical Trials

 

We are actively enrolling equine patients in a pre-clinical safety/efficacy study for the use of INSPIRE to treat cutaneous melanoma. Please contact us for details.

 

We are preparing for safety / efficacy studies for the use of INSPIRE to treat canine breast, liver, and brain tumors. Please contact us for details.

 

Publications

 

 

Thermochromic Tissue Phantoms for Evaluating Temperature Distribution in Simulated Clinical Applications of Pulsed Electric Field Therapies

 

BioElectricity

 

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Irreversible Electroporation is a Thermally Mediated Ablation Modality for Pulses on the Order of One Microsecond

 

Bioelectrochemistry

 

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Electro-Thermal Therapy: Microsecond Duration Pulsed Electric Field Tissue Ablation with Dynamic Temperature Control Algorithms

 

Computers in Biology and Medicine

 

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Electro-Thermal Therapy and Active Internal Electrode Cooling Reduce Thermal Injury in High Frequency Pulsed Electric Field Cancer Therapies

 

Annals of Biomedical Engineering

 

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Temperature Dependence of High Frequency Irreversible Electroporation Evaluated in a 3D Tumor Model

 

Annals of Biomedical Engineering

 

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Algorithmically Controlled Electroporation: A Technique for Closed Loop Temperature Regulated Pulsed Electric Field Cancer Ablation

 

IEEE Transactions on Biomedical Engineering

 

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Bipolar High-Frequency Pulses Using A Single Insertion Device Enable Simplified, Non-Thermal Tissue Ablation

 

IEEE Transactions on Biomedical Engineering

 

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High Frequency Irreversible Electroporation Using 5000V Waveforms to Create Reproducible 2 and 4 centimeter Ablation Zones

 

Journal of Vascular and Interventional Radiology (JVIR)

 

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Burst and Continuous High Frequency Irreversible Electroporation Protocols Evaluated in a Three Dimensional Tumor Model

 

Physics in Medicine and Biology

 

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Optimization of a Single Insertion Electrode Array for the Creation of Clinically Relevant Ablations Using High-Frequency Irreversible Electroporation

 

Computers in Biology and Medicine

 

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Reduction of Muscle Contractions during Irreversible Electroporation Therapy Using High Frequency Bursts of Alternating Polarity Pulses

 

Journal of Vascular and Interventional Radiology (JVIR)

 

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Treatment of Cancer In Vitro Using Radiation and High-Frequency Bursts of Submicrosecond Electrical Pulses

 

IEEE Transactions on Biomedical Engineering

 

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A Comprehensive Characterization of Parameters Affecting High-Frequency Irreversible Electroporation Lesions

 

Annals of Biomedical Engineering

 

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Asymmetric Waveforms Decrease Lethal Thresholds in High Frequency Irreversible Electroporation Therapies

 

Nature Scientific Reports

 

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Production of Spherical Ablations using Non-Thermal Irreversible Electroporation – A Laboratory Investigation Using a Single Electrode and Grounding Pad

 

Journal of Vascular and Interventional Radiology  (JVIR) 

 

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Targeted Cellular Ablation Based On The Morphology of Malignant Cells

 

Nature Scientific Reports

 

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